Maze Therapeutics Announces Positive Topline Data from Phase 2 HORIZON Trial of MZE829 Demonstrating the First Clinical Proof-of-Concept in Patients with Broad APOL1-Mediated Kidney Disease
Maze Therapeutics reported promising topline results from its Phase 2 HORIZON trial of MZE829, an oral dual-mechanism APOL1 inhibitor targeting APOL1-mediated kidney disease. Treatment resulted in a 35.6% mean reduction in proteinuria (uACR) at week 12 across a broad AMKD patient population, with enhanced efficacy in FSGS patients (61.8% reduction)…