Press Releases March 27, 2026

ORIC® Pharmaceuticals to Report Combination Dose Optimization Data From Phase 1b Trial of Rinzimetostat in Patients with mCRPC

ORIC Pharmaceuticals to Present Phase 1b Combination Dose Optimization Data for Rinzimetostat in mCRPC Patients

By Ajmal Hussain ORIC
ORIC® Pharmaceuticals to Report Combination Dose Optimization Data From Phase 1b Trial of Rinzimetostat in Patients with mCRPC
ORIC

ORIC Pharmaceuticals announced plans to report combination dose optimization data from its Phase 1b trial of rinzimetostat in metastatic castration resistant prostate cancer patients. The presentation will occur during a webcast and conference call on March 31, 2026. This update provides insights into dosing strategies for an investigational allosteric inhibitor targeting the PRC2 complex, advancing their clinical development portfolio in oncology.

Key Points

  • ORIC will share data from a Phase 1b trial of rinzimetostat (ORIC-944) targeting metastatic castration resistant prostate cancer (mCRPC).
  • The data focus on combination dose optimization, which is critical for establishing effective dosing regimens in further clinical development.
  • ORIC’s pipeline includes investigational therapies targeting mechanisms of therapeutic resistance in cancer, impacting oncology and biopharmaceutical sectors.

SOUTH SAN FRANCISCO, Calif. and SAN DIEGO, March 27, 2026 (GLOBE NEWSWIRE) -- ORIC Pharmaceuticals, Inc. (Nasdaq: ORIC), a clinical stage oncology company focused on developing treatments that address mechanisms of therapeutic resistance, today announced that it will report combination dose optimization data from the Phase 1b trial of rinzimetostat (ORIC-944) in patients with metastatic castration resistant prostate cancer (mCRPC) in a conference call and webcast on Tuesday, March 31, 2026 at 4:30pm ET.

To join the conference call via phone and participate in the live Q&A session, please pre-register online here to receive a telephone number and unique passcode required to enter the call. A live webcast and audio archive of the conference call will be available through the investor section of the company’s website at www.oricpharma.com. The webcast will be available for replay for 90 days following the presentation.

About ORIC Pharmaceuticals, Inc.
ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer. ORIC’s clinical stage product candidates include (1) rinzimetostat (ORIC-944), an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (2) enozertinib (ORIC-114), a brain-penetrant inhibitor targeting EGFR exon 20 and EGFR PACC mutations, being developed for NSCLC. ORIC has offices in South San Francisco and San Diego, California. For more information, please go to www.oricpharma.com, and follow us on X or LinkedIn.

Contact:
Dominic Piscitelli, Chief Financial Officer
dominic.piscitelli@oricpharma.com
info@oricpharma.com


Risks

  • Phase 1b trial results are preliminary and may not predict later-stage clinical success, posing clinical development risk to ORIC.
  • Combination dose optimization findings may lead to dose adjustments that could impact efficacy and safety profiles, affecting regulatory approval timelines.
  • Dependency on clinical trial progress and data releases makes ORIC's stock sensitive to clinical milestones and oncology drug development uncertainties.

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