Press Releases April 29, 2026 09:00 AM

Codexis to share RNA manufacturing advances at TIDES USA

Codexis to present new RNA manufacturing platform advances and lead industry panel at TIDES USA conference

By Hana Yamamoto
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CDXS

Codexis, a US-based enzymatic solutions provider, will showcase advancements in its ECO Synthesis® manufacturing platform for RNAi therapeutics at the TIDES USA conference. The company will present data highlighting improved process control, phosphorothioate stereochemistry management, enhanced ligation efficiency, and sustainability benefits. Codexis will also host an expert panel discussing stereochemical control implications in RNAi manufacturing, underscoring its industry leadership and innovation in scalable, sustainable RNA therapeutics production.

Codexis to share RNA manufacturing advances at TIDES USA
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Key Points

  • Codexis presents new data on enzymatic RNA manufacturing advances improving efficiency, yield, and sustainability.
  • Company emphasizes control of phosphorothioate stereochemistry and superior ligation techniques critical for scalable RNAi therapeutic production.
  • Hosting an expert panel with notable industry leaders to address challenges and innovations in RNAi manufacturing, reinforcing Codexis' role in the sector.

REDWOOD CITY, Calif., April 29, 2026 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ: CDXS) a leading provider of enzymatic solutions for efficient and scalable therapeutics manufacturing, will present new data on ECO Synthesis® Manufacturing Platform and provide an update on regulatory engagement for its enzymatic platform at TIDES USA, held May 11–14 at the Hynes Convention Center in Boston.

As RNAi therapies expand into larger indications, manufacturing scalability, maintaining process control and delivering high-quality product is critical. Codexis will present data demonstrating advances in controlling phosphorothioate stereochemistry, improved ligation efficiency and process performance, alongside the sustainability advantages of siRNA manufacturing approaches.

Codexis’ technical experts will present at three sessions during the conference:

Spotlight Presentation:
Controlling Phosphorothioate Stereochemistry: Challenges and Innovations in Oligonucleotide Manufacturing
Stefan Lutz, PhD., Chief Scientific Officer
Thursday, May 14, 8:30–9:00 a.m.

TIDES Talk:
Superior Ligation Solutions for Scalable RNA Manufacturing
Derek Gauntlett, Vice President, Development
Wednesday, May 13, 10:25–10:35 a.m.

Conference Presentation:
Advancing Sustainability through Innovation in Oligonucleotide Manufacturing
David Entwistle, PhD., Senior Director, Program and Pipeline Management
Wednesday, May 13, 4:15–4:45 p.m.

In addition to Codexis’ talks and booth (821) presence at TIDES USA, Codexis will also host an expert panel discussion and networking event, “Stereochemistry in RNAi Manufacturing: Signal or Noise?”, on Tuesday, May 12. This panel will explore the growing industry focus on stereochemical control, manufacturing options, and its implications for therapeutic performance, and product quality. Panellists include:

  • John Maraganore, PhD., Founder and Former CEO at Alnylam
  • Fred Fleitz, PhD., SVP of CMC and Development Chemistry at Arrowhead Pharmaceuticals
  • Alison Moore, PhD., President and CEO at Codexis
  • Raman Sehgal, Entrepreneur, and Host of the Molecule to Market Podcast

About Codexis, Inc.

Codexis is a leading provider of enzymatic solutions for efficient and scalable therapeutics manufacturing, leveraging its proprietary CodeEvolver® technology platform to discover, develop and enhance novel, high-performance enzymes. Codexis enzymes solve for real-world challenges associated with small molecule pharmaceuticals manufacturing and nucleic acid synthesis. The Company is currently developing its proprietary ECO Synthesis manufacturing platform to enable the scaled manufacture of RNAi therapeutics through an enzymatic route. Codexis’ unique enzymes can drive improvements such as higher yields, reduced energy usage and waste generation, improved efficiency in manufacturing and greater sensitivity in genomic and diagnostic applications. For more information, visit codexis.com.

For investor inquiries:
Georgia Erbez
(650) 421-8100
ir@codexis.com

For media inquiries:
aranda@ramarketingpr.com


Risks

  • Regulatory engagement and approval for enzymatic manufacturing platform advancements remain uncertain and may impact commercialization timelines.
  • Market adoption of RNAi therapeutics manufacturing processes could be slow or face competition from alternative technologies.
  • Operational scale-up challenges or process control issues could hinder consistent production quality and cost benefits.

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